EULAR 2022: A glimpse of Abbvie’s Oral Presentation on Upadacitinib for treatment of Nonradiographic Axial Spondyloarthritis

Upadacitinib for treatment of Nonradiographic Axial Spondyloarthritis

Janus Kinase (JAK) inhibitors have been recognized as a probable treatment option for  Ankylosing spondylitis (AS), also known as radiographic axial spondyloarthritis (r-axSpA). Upadacitinib, an inhibitor by JAK, has shown efficacy and safety in treating  Ankylosing spondylitis (AS), and so far no JAK inhibitor studies in non-radiographic axSpA (nr-SpA) have done such.


The efficacy and safety findings of upadacitinib (RINVOQ) in patients with nr-axSpA and patients with AS who have not responded to biologic disease-modifying antirheumatic drugs (bDMARDs) are highlighted in the SELECT-AXIS 2 trial.


SELECT-AXIS 2 (Study 2) is a Phase III trial evaluating upadacitinib's effectiveness and safety in patients with active nr-axSpA.


At Week 14, upadacitinib met the primary endpoint of the Assessment in SpondyloArthritis International Society (ASAS) 40 response and the majority of the secondary endpoints, according to the interim results. At Week 14, upadacitinib-treated patients had a significantly higher rate of ASAS40 response (45%) than placebo-treated patients (23 percent ).


In January of this year, the company submitted applications to the US FDA and the European Medicines Agency (EMA) for approval of upadacitinib (RINVOQ, 15 mg once daily) for the treatment of adults with active nr-axSpA and objective signs of inflammation who have failed to respond to nonsteroidal anti-inflammatory drugs (NSAIDs).


Conclusion


The disease activity of 30% of individuals with SpA cannot be controlled with currently approved medicines, according to the current spondyloarthritis therapy regimen.


JAK inhibitors are a new family of nonbiologic (synthetic) disease-modifying antirheumatic drugs (DMARDs) that have shown to be successful in clinical trials for the treatment of psoriatic arthritis and ankylosing spondylitis. Furthermore, because it is administered orally, it is a more convenient treatment option than other medications, which may lead to higher compliance.

For more detailed information visit: https://www.delveinsight.com/eular-conference/eular-2022

 

Some of the Latest Abstracts launched in EULAR 2022:

 

Diagnostic Imaging Equipment Market

Diagnostic Imaging Equipment Market By Product (X-Ray Imaging Systems, Computed Tomography (CT) Scanners, Ultrasound Systems, Magnetic Resonance Imaging (MRI) Systems, Nuclear Imaging Systems, Mammography Systems, And Others), By Application (Cardiology, Oncology, Gastroenterology, Gynecology, And Other Applications), By End-User (Hospitals, Diagnostic Imaging Centres, And Others), by geography is expected to grow at a steady CAGR forecast till 2026 owing to rising technological advancement and increasing prevalence of chronic diseases.

 

Invasive Candidiasis Market

"DelveInsight’s ‘Invasive Candidiasis Market Insight, Competitive Landscape and Market Forecast, 2027’ report delivers an in-depth understanding of Invasive Candidiasis and the historical and forecasted Invasive Candidiasis market trends, globally, which comprises North America, Europe, APAC, and RoW.

 

Sialidosis Market 

DelveInsight's "Sialidosis Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of the Sialidosis, historical and forecasted epidemiology as well as the Sialidosis market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

 

Filgrastim Biosimilar Insight

DelveInsight’s, “Filgrastim Biosimilar Insight, 2022,” report provides comprehensive insights about 20+ companies and 20+ marketed and pipeline drugs in the Filgrastim Biosimilars landscape. It covers the marketed and pipeline drug profiles, including clinical and non-clinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. 

 

Pain Management Devices Market

Pain Management Devices Market By Type Of Devices (Neuromodulation & Neurostimulation Devices, Analgesic Infusion Pumps [Intrathecal Infusion Pumps and External Infusion Pumps], Ablation Devices [Radiofrequency Ablation Devices And Cryoablation Devices], And Others), By Application (Neuropathic Pain, Cancer Pain, Facial & Migraine Pain, Musculoskeletal Pain, and Others), By Geography is expected to grow at a steady CAGR Forecast till 2027.

 

To know more about our Competitive Services, Click here: Pharma Competitive Intelligence

https://www.delveinsight.com/consulting/competitive-intelligence-services


Also, take a glance at the Blogs by DelveInsight:

Comments

Post a Comment

Popular posts from this blog

Innovations in Surgical Cameras and Their Impact on Healthcare

Image
  The Evolution of Surgical Cameras Surgical cameras have revolutionized modern medicine by enabling detailed visualization during procedures that were once only performed through open surgeries. The evolution of these cameras has been marked by advancements in technology, allowing for higher resolution images and improved maneuverability within the surgical field. From bulky, early prototypes to sleek, high-definition cameras, their development has significantly enhanced surgical precision and patient outcomes. Types of Surgical Cameras Various types of surgical cameras cater to different medical needs. Endoscopy cameras, for instance, are crucial in minimally invasive surgeries (MIS), providing clear visualization inside the body without large incisions. These cameras come in rigid and flexible forms, each suited for specific anatomical areas and procedures. The market for endoscopy cameras, a subset of the global surgical camera market , continues to grow as demand increases fo...
Read more

What is Chronic Wounds and why is its market booming?

Image
The Chronic Wounds market is expected to surge due to the disease's increasing prevalence and awareness during the forecast period. Furthermore, launching various multiple-stage Chronic Wounds pipeline products will significantly revolutionize the Chronic Wounds market dynamics.    DelveInsight’s “ Chronic Wounds Market Insights , Epidemiology, and Market Forecast-2032″ report offers an in-depth understanding of the Chronic Wounds, historical and forecasted epidemiology as well as the Chronic Wounds market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan. The Chronic Wounds market report covers emerging drugs, current treatment practices, market share of the individual therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current treatment practice/algorithm, market drivers & barriers, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of...
Read more

Condom Market Report 2028: Market Size, Trends, and Forecast

Image
  What is a Condom? A condom is a barrier contraceptive device made of latex, polyurethane, or lambskin that is designed to prevent the transmission of sexually transmitted infections (STIs) and unintended pregnancies. It is one of the most widely used methods of protection during sexual activity. What is the market for Global Condom? The global Condom market is robust and continues to witness significant growth. This market is driven by the dual benefits of protection against STIs and contraception. Moreover, the market is evolving with the introduction of innovative and user-friendly condom designs, attracting a broader demographic. What are the Condom market drivers? The Condom Market Drivers are illustrated as follows- 1. Public Health Initiatives: Public health campaigns promoting safe sex and the prevention of STIs and unintended pregnancies drive condom use. 2. Increasing Awareness: Growing awareness of the importance of safe sex practices and the benefits of condom use...
Read more